Dr Vu Gia Phong

1. Working

2020 – Present:  Head of Department of Chemistry, Biochemistry, Microbiology, Hong Bang International University (HIU)                                 

2015-2019- Scientific Investigator, University of Califrornia – Berkeley

2009-2014 – Lab Biosafety Officer/ Manager

2. Projects

1. Researches in the field of applied biomedical engineering and molecular therapy with focus on molecular treatment using molecular scissors such as Rnase P, CRISPR-Cas-9, TALEN, …
2. Basic research on bacteria and viruses with emphasis on STI viruses such as HCMV, KSV, HSV-1,2, HIV, etc.
3. Research on the body's immune response to bacteria and viruses for the development of vaccines and therapeutic serums.

Peer Review Journals

1. 1. Feng L, Sheng J, Vu GP, Liu Y, Foo C, Wu S, Trang P, Paliza-Carre M, Ran Y,Yang X, Sun X, Deng Z, Zhou T, Lu S, Li H, Liu F. Human cytomegalovirus UL23 inhibits transcription of interferon-γ stimulated genes and blocks antiviral interferon-γ responses by interacting with human N-myc interactor protein. PLoS

Pathog. 2018 Jan 29;14(1):e1006867. doi: 10.1371/journal.ppat.1006867.eCollection 2018 Jan. PubMed PMID: 29377960; PubMed Central PMCID: PMC5805366.

2. 2. Li W, Sheng J, Xu M, Vu GP, Yang Z, Liu Y, Sun X, Trang P, Lu S, Liu F. Inhibition of Murine Cytomegalovirus Infection in Animals by RNase P-Associated External Guide Sequences. Mol Ther Nucleic Acids. 2017 Dec 15;9:322-332. doi: 10.1016/j.omtn.2017.10.007. Epub 2017 Oct 16. PubMed PMID: 29246310; PubMed Central PMCID: PMC5684469.

3. 3. Sun X, Chen W, He L, Sheng J, Liu Y, Vu GP, Yang Z, Li W, Trang P, Wang Y, Hai R, Zhu H, Lu S, Liu F. Inhibition of human cytomegalovirus immediate early gene expression and growth by a novel RNase P ribozyme variant. PLoS One. 2017 Oct 23;12(10):e0186791. doi: 10.1371/journal.pone.0186791. eCollection 2017. PubMed PMID: 29059242; PubMed Central PMCID: PMC5653336.

4. 4. Liu MY, Liu J, Lai W, Luo J, Liu Y, Vu GP, Yang Z, Trang P, Li H, Wu J. Characterization of enterovirus 71 infection and associated outbreak of Hand, Foot, and Mouth Disease in Shawo of China in 2012. Sci Rep. 2016 Dec 12;6:38451. doi: 10.1038/srep38451. PubMed PMID: 27941929; PubMed Central PMCID: PMC5150535.

5. 5. Liu J, Shao L, Trang P, Yang Z, Reeves M, Sun X, Vu GP, Wang Y, Li H, Zheng C, Lu S, Liu F. Inhibition of herpes simplex virus 1 gene expression and replication by RNase P-associated external guide sequences. Sci Rep. 2016 Jun 9;6:27068. doi: 10.1038/srep27068. PubMed PMID: 27279482; PubMed Central PMCID: PMC4899697.

6. 6. Yang Z, Vu GP, Qian H, Chen YC, Wang Y, Reeves M, Zen K, Liu F. Engineered RNase P ribozymes effectively inhibit human cytomegalovirus gene expression and replication. Viruses. 2014 Jun 13;6(6):2376-91. doi: 10.3390/v6062376. PubMed PMID: 24932966; PubMed Central PMCID: PMC4074932.

7. 7. Vu GP,Yang Z, Gong H, Xia C, Chen YC, Liu F, Wu J, Lu S. Engineered externalguide sequences are highly effective in inhibiting gene expression and replication of hepatitis B virus in cultured cells. PLoS One. 2013 Jun 12;8(6):e65268. doi: 10.1371/journal.pone.0065268. Print 2013. PubMed PMID: 23776459; PubMed Central PMCID: PMC3680410.

8. 8. Zeng W, Vu GP, Bai Y, Chen YC, Trang P, Lu S, Xiao G, Liu F. Rnase P-associated external guide sequence effectively reduces the expression of human CC-chemokine receptor 5 and inhibits the infection of human immunodeficiency virus 1. Biomed Res Int. 2013;2013:509714. doi: 10.1155/2013/509714. Epub 2012 Dec 27. PubMed PMID: 23509733; PubMed Central PMCID: PMC3591226.

9. 9. Xia C, Chen YC, Gong H, Zeng W, Vu GP, Trang P, Lu S, Wu J, Liu F. Inhibition of hepatitis B virus gene expression and replication by ribonuclease P. Mol Ther. 2013 May;21(5):995-1003. doi: 10.1038/mt.2013.37. Epub 2013 Mar 12. PubMed PMID: 23481322; PubMed Central PMCID: PMC3666634.

10. 10. Zeng W, Chen YC, Bai Y, Trang P, Vu GP, Lu S, Wu J, Liu F. Effective inhibition of human immunodeficiency virus 1 replication by engineered RNase P ribozyme. PLoS One. 2012;7(12):e51855. doi: 10.1371/journal.pone.0051855. Epub 2012 Dec 26. PubMed PMID: 23300569; PubMed Central PMCID: PMC3530568.

11. 1 Jiang X, Gong H, Chen YC, Vu GP, Trang P, Zhang CY, Lu S, Liu F. Effective inhibition of cytomegalovirus infection by external guide sequences in mice. Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13070-5. doi: 10.1073/pnas.1201620109.Epub 2012 Jul 23. PubMed PMID: 22826233; PubMed Central PMCID: PMC3420183.

12. 12. Gong H, Vu GP, Bai Y, Chan E, Wu R, Yang E, Liu F, Lu S. A Salmonella small non-coding RNA facilitates bacterial invasion and intracellular replication by modulating the expression of virulence factors. PLoS Pathog. 2011 Sep;7(9):e1002120. doi: 10.1371/journal.ppat.1002120. Epub 2011 Sep 15. PubMed PMID: 21949647; PubMed Central PMCID: PMC3174252.

13. 13. Bai Y, Gong H, Li H, Vu GP, Lu S, Liu F. Oral delivery of RNase P ribozymes by Salmonella inhibits viral infection in mice. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3222-7. doi: 10.1073/pnas.1014975108. Epub 2011 Feb 7. PubMed PMID: 21300908; PubMed Central PMCID: PMC3044408.

14. 14. Kim K, Yang E, Vu GP, Gong H, Su J, Liu F, Lu S. Mass spectrometry-based quantitative proteomic analysis of Salmonella enterica serovar Enteritidis protein expression upon exposure to hydrogen peroxide. BMC Microbiol. 2010 Jun 8;10:166. doi: 10.1186/1471-2180-10-166. PubMed PMID: 20529336; PubMed CentralPMCID: PMC2897801.

15. 15. Bai Y, Li H, Vu GP, Gong H, Umamoto S, Zhou T, Lu S, Liu F. Salmonella-mediated delivery of RNase P-based ribozymes for inhibition of viral gene expression and replication in human cells. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7269-74. doi: 10.1073/pnas.0912813107. Epub 2010 Apr 1. PubMed PMID: 20360564; PubMed Central PMCID: PMC2867731.

16. 16. Gong H, Vu GP, Bai Y, Yang E, Liu F, Lu S. Differential expression of Salmonella type III secretion system factors InvJ, PrgJ, SipC, SipD, SopA and SopB in cultures and in mice. Microbiology. 2010 Jan;156(Pt 1):116-27. doi:10.1099/mic.0.032318-0. Epub 2009 Sep 17. PubMed PMID: 19762438; PubMed Central

PMCID: PMC2889428.